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1
題名:改善腫瘤微環境與放射敏感性的關係     (14點)
THE CORRELATION BETWEEN IMPROVING TUMOR MICROENVIRONMENT AND RADIO-SENSITIZATION
著者:王愈善(Yu-Shan Wang) ;季匡華(Kwan-Hwa Chi)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:放射治療 ; 放射增敏 ; 腫瘤微環境 ; 免疫細胞 ; 血管新生 ; Radiotherapy ; Radiosensitization ; Tumour microenvironment ; Immune cells ; Angiogenesis
刊名:放射治療與腫瘤學
頁碼:225-231
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

腫瘤細胞周圍的外在環境會影響放射反應的成效,而在腫瘤微環境中的內皮細胞和免疫浸潤細胞則是顯著影響放射治療結果的兩個關鍵因子之一。在分次放療中,會引發HIF-1和VEGF的增加,因而降低分次放療的優勢。另外,抗血管新生藥物的療效會被腫瘤微環境中的內生性血管生成前趨細胞所中和。除了血管之外,淋巴細胞也在腫瘤微環境中扮演很重要的角色。免疫細胞的組成種類不同,對於放射治療的效果也有很大的影響。在這篇文章中,我們探討了最近一些針對腫瘤微環境中免疫細胞重要性的文獻。目前正在發展中的合併放射治療以及免疫治療或其他調控整個腫瘤微環境的方式,有可能在不久的將來會有豐碩的成果。
Radioresponse is influenced by factors extrinsic to cancer cells. Endothelial cells and infiltrating immune cells within the tumour microenvironment are the two components that significantly affect the outcome of radiotherapy. The benefits of fractionated radiotherapy are reduced by up-regulation of hypoxia inducible factor-1α (HIF-1α) and vasculoendothelial growth factor (VEGF). Further, the therapeutic effect of anti-angiogenic agents is counteracted by the mobilization of endogenous proangiogenic cells into the tumour microenvironment. In addition to endothelial cells, immune cells play an important role in the microenvironment that regulates tumour growth and response to therapy. In this review, we highlight some of the recent studies on the importance of immune cells in the microenvironment. The progress in developing combinations of radiotherapy and immunotherapy or other methods for modulation of the tumour immune microenvironment may yield fruitful results in the near future.


    

本卷期目次
放射治療與腫瘤學
ONCE-DAILY AND TWICE-DAILY RADIOTHERAPY WITHOUT CHEMOTHERAPY IN THE TREATMENT OF MALIGNANT GLIOMA/ Yu-Nong WangJing-Min HwangYee-Min JenChang-Min Chen
ELDERLY OROPHARYNX-HYPOPHARYNX CARCINOMA PATIENTS: INDUCTION CHEMOTHERAPY PLUS CHEMORADIOTHERAPY IMPROVE CANCER CONTROLS THAN RADIOTHERAPY ALONE/ Yao-Wen ChangMoon-Sing LeeShih-Kai HungWen-Yen ChiouWen-Lin HsuDai-Wei LiuYu-Chieh SuJing-Min HwangSzu-Chi LiHon-Yi Lin
CLINICAL IMPLICATIONS OF TUMOR VOLUME IN PATIENTS WITH THE BASE OF TONGUE CANCER TREATED WITH DEFINITIVE INTENSITY-MODULATED RADIOTHERAPY TECHNIQUE/ Shih-Chieh LinShih-Neng YangYao-Ching WangJi-An LiangYu-Cheng KuoFang-Jen LinShang-Wen Chen
LIMITED-STAGE SMALL CELL CARCINOMA OF ESOPHAGUS: A SINGLE INSTITUTION EXPERIENCE/ Forn-Chia LinLing-Wei WangMing-Wei YangSang-Hue Yen
UPDATE IN THE MANAGEMENT OF LOCALLY ADVANCED PANCREATIC CANCER-FOCUSING ON THE STRATEGY OF INDUCTION CHEMOTHERAPY FOLLOWED BY CHEMORADIOTHERAPY/ Hui-Ju Ch'angHelen Hw ChenLi-Tzong Chen
改善腫瘤微環境與放射敏感性的關係/ 王愈善季匡華
使用廣義等效均勻劑量(gEUD)為優化基礎的劑量體積目標之雙邊乳癌強度調控放射治療計劃/ 丁慧敏李財福趙珮如李曉飛黃英彥黃郁傑方富民卓明遠陳惠君
TOTAL BODY IRRADIATION WITH LATERAL TREATMENT TECHNIQUE USING WATER BAGS AS TISSUE COMPENSATORS/ Chu-Ping PiMu-Tai LiuTung-Hao ChangSheng-Shien HuangKuang-Hsuan Lin
CARCINOMA SHOWING THYMUS-LIKE DIFFERENTIATION (CASTLE) OF THE NECK: A CASE REPORT AND REVIEW OF THE LITERATURE/ Chia-Chun ChenWan-Lin ShenSung-Wei LiLi-Ching LinYu-Wen Wang
 
   
 
   

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