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1
題名:TREATMENT OUTCOMES FOR SYNCHRONOUS OR METACHRONOUS HYPOPHARYNGEAL/LARYNGEAL/OROPHARYNGEAL CANCER AND ESOPHAGEAL CANCER     (22點)
同時或異時發生之口咽、咽喉或下咽癌及食道癌之治療結果
著者:Che-Yu Hsu(許哲瑜) ;Jason Chia-Hsien Cheng(成佳憲) ;Sung-Hsin Kuo(郭頌鑫) ;Yu-Hsuan Chen(陳育瑄) ;Chiao-Ling Tsai(蔡巧琳) ;Keng-Hsueh Lan(藍耿學) ;Wan-Yu Chen(陳婉瑜) ;Chun-Wei Wang(王駿瑋)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:下咽 ; 口咽 ; 咽喉 ; 食道 ; Hypopharynx ; Oropharynx ; Larynx ; Esophagus
刊名:Therapeutic Radiology and Oncology
頁碼:119-129
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:呈現頭頸部上皮癌(口咽、咽喉及下咽癌)伴隨同時或異時發生食道癌的病人,近十年來之治療經驗。 材料及方法:本研究含1998至2008年,罹患同時或異時發生的口咽癌、咽喉或下咽癌及食道癌的病人。同時發生的定義為兩種腫瘤發生的時間在六個月內,異時發生的定義是兩種癌症發生的時間間隔大於六個月。在食道腫瘤的治療,有11位病人最終有接受手術切除,其餘22位病人則只接受放(化)療。在頭頸癌治療方面,有15個人接受手術切除,其餘18人只有接受放化療。 結果:共33位病人收錄進本研究,其中10人罹患同時發生的癌症,其餘23人有異時發生的癌症。在本研究存活病人追蹤時間的中位數是41.3個月。所有病人存活時間及無疾病存活時間的中位數分別是13.6及9.3個月。在單變數分析中,對於存活時間與無疾病存活時間的良好預後因子為早期的食道癌。食道腫瘤的手術切除在預後方面有較佳的趨勢。 結論:同時或異時發生的口咽癌、咽喉或下咽癌及食道癌常伴隨著不好的治療結果。發現時為早期之食道腫瘤能伴隨著較佳的預後。能以手術治療食道腫瘤的病人,在無疾病存活時間也有較佳的結果。
Purpose: To evaluate the treatment of synchronous or metachronous hypopharyngeal/laryngeal/oropharyngeal head and neck cancer (H&N cancer) and esophageal cancer in our institution. Materials and Methods: The retrospective study included patients with synchronous or metachronous H&N and esophageal cancer treated at our institution from 1998 to 2008. A synchronous malignancy was defined as a second malignancy diagnosed within 6 months after the initial diagnosis of cancer. A metachronous malignancy was defined as a second malignancy diagnosed more than 6 months after the initial diagnosis of cancer. For the treatment of esophageal cancer, 11 patients underwent surgery with or without neoadjuvant concurrent chemo-radiotherapy (CCRT), and the other 22 patients received definitive radiotherapy with or without concurrent chemotherapy. For the treatment of H&N cancer, 15 patients underwent surgical intervention with or without adjuvant CCRT, and the other 18 patients received definitive CCRT. Results: Our study included 33 patients. Among these patients, 10 presented with synchronous H&N and esophageal cancer, and 23 patients developed metachronous carcinomas. The median age at primary diagnosis was 56.8 years (range: 40.7-79.6 years). The median follow-up time for living patients was 41.3 months. For the entire group, the median overall survival time (OS) and disease-free survival time (DFS) were 13.6 and 9.3 months, respectively. Univariate analysis revealed that T stage of esophageal cancer (T1/T2 vs. T3/T4) was a significant prognostic factor for OS and DFS (22.5 vs. 12.2 months [p=0.041], and 21.3 vs. 8.5 months [p=0.020], respectively). In the case of synchronous or metachronous esophageal cancer, surgical intervention was associated with a better outcome than radiotherapy, with borderline significance (p=0.076). Conclusions: Patients with synchronous or metachronous H&N and esophageal cancer had poor outcomes. Those with T1/T2 esophageal cancer had a better chance for survival than those with T3/T4 esophageal cancer. This result implies that the T stage of esophageal cancer is a prognosis-limiting factor. Routine screening for synchronous or metachronous esophageal cancer may facilitate early detection and thereby improve the outcomes.


    

本卷期目次
Therapeutic Radiology and Oncology
COMPARING STEREOTACTIC BODY RADIOTHERAPY WITH THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY FOR PATIENTS WITH UNRESECTABLE OR RECURRENT HEPATOCELLULAR CARCINOMA/ Jang-Chun LinYee-Min JenWen-Yen HuangChang-Min ChenHsing-Lung ChaoChun-Shun LinYu-Fu SuKuen-Tze LinWei-Yuan NienMiao-Jung Lin
TREATMENT OUTCOMES FOR SYNCHRONOUS OR METACHRONOUS HYPOPHARYNGEAL/LARYNGEAL/OROPHARYNGEAL CANCER AND ESOPHAGEAL CANCER/ Che-Yu HsuJason Chia-Hsien ChengSung-Hsin KuoYu-Hsuan ChenChiao-Ling TsaiKeng-Hsueh LanWan-Yu ChenChun-Wei Wang
EVALUATE THE ACCURACY OF VMAT FOR CLINICAL USE-THE INITIAL EXPERIENCE OF SMARTARC APPLICATION/ Su-Hua LoYu-Wen WangCyong-Lian GuoChing-Yu ChangSung-Wei Lee
IMPROVEMENT OF SETUP ACCURACY BY NECK-SHOULDER BAG DURING RADIOTHERAPY IN HEAD AND NECK CANCER PATIENTS/ Pei-Hua FanChen-Yuan ChenYi-Chen LiuShiue-Shiun ChenYen-Chao ChenChieh-Sheng TsaiJih-Hong HongWai-Man Leung
SIMULTANEOUS INTEGRATED BOOST INTENSITY-MODULATED RADIOTHERAPY FOR LOCALLY ADVANCED ANAPLASTIC THYROID CANCER/ Yu-Ming WangChun-Chieh HuangHui-Min TingChong-Jong Wang
OSTEOSARCOMA AFTER IRRADIATED NASOPHARYNGEAL CARCINOMA: A CASE REPORT/ I-Chun YehMing-Yang LeeJenn-Ren HsiaoSen-Tien TsaiHelen H. W. ChenJin-Ching Lin
EVALUATION OF LUNG VOLUME/DOSE IN BREAST CANCER IRRADIATION AFTER MODIFIED RADICAL MASTECTOMY VERSUS BREAST CONSERVATIVE SURGERY/ Li-Min SunJi-An LiangFan-Yun MengTsung-Han YangMin-Jen Tsao
CLINICAL CHARACTERISTICS, IMAGE FINDINGS, AND TREATMENT MODALITIES ASSOCIATE WITH OUTCOMES OF PATIENTS WITH GLIOBLASTOMA MULTIFORME/ Hsiang-Kuang LiangChao-Yuan HuangChun-Wei WangYu-Hsuan ChenSung-Hsin KuoJason Chia-Hsien Cheng
 
   
 
   

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