原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
老人需求dvdPerception直播
   
   
   
     
   
 
項次 書目
1
題名:FEASIBILITY STUDY USING PRE-OPERATIVE PRONE-POSITION VOLUMETRIC MODULATED ARC THERAPY AND CHEMOTHERAPY IN LOCALLY ADVANCED RECTAL CANCER     (20點)
術前俯臥弧形調控放射治療合併化學治療於局部嚴重性直腸癌之可行性研究
著者:Chia-Chun Wang(王嘉儁) ;Chiao-Ling Tsai(蔡巧琳) ;Yu-Hsuan Chen(陳育瑄) ;Jin-Tung Liang(梁金銅) ;Ming-Jium Shieh(謝銘鈞) ;Ben-Ren Lin(林本仁) ;Yu-Lin Lin(林育麟) ;Jason Chia-Hsien Cheng(成佳憲)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:直腸癌 ; 俯臥 ; 弧形調控放射治療 ; Rectal cancer ; Prone position ; Volumetric modulated arc therapy
刊名:Therapeutic Radiology and Oncology
頁碼:13-22
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:評估術前俯臥弧形調控放射治療合併化學治療,於局部嚴重性直腸癌病患之治療副作用以及初步治療成效。
材料與方法:自西元2010年4月至2010年10月,十位臨床分期為二至四期之直腸癌病患接受了術前俯臥弧形調控放射治療合併化學治療。所有病患皆使用腹板(belly board)以及漲尿治療。所有治療計畫皆是45 Gy分25次治療,並以Pinnacle3 9.0軟體設計。擺位誤差以至少每週一次的錐束電腦斷層(cone-beam computed tomography)校正。治療之副作用以Common Terminology Criteria for Adverse Events v4.0作為評估工具。化學治療主要以5-fluorouracil搭配oxaliplatin或是mitomycin。五位病患同時使用了bevacizumab。
結果:所有的病人皆完成了術前合併放射化學治療,也都接受了手術切除。兩位使用bevacizumab的病人達到了病理完全反應(pathological complete response)。九位病人達到了病理上的期別下降(downstaging)。只有一個病人病理上有淋巴結的轉移。最常見的副作用是第一級或第二級的肛門皮膚反應或腹瀉。沒有任何病患有第三級或以上的副作用。病患的副作用和是否使用bevacizumab無關。平均擺位誤差在頭腳、左右及前後方向分別為0.24公分、0.21公分及0.37公分。擺位誤差之標準差之範圍在頭腳、左右及前後方向分別為0.09-0.34公分、0.06-0.20公分及0.11-0.52公分。
結論:不論是否合併使用bevacizumab,術前俯臥弧形調控放射治療合併化學治療是可行且安全的。治療造成的副作用在可接受的範圍,治療之反應也有不錯的成效。俯臥姿勢需要多注意擺位誤差的校正。
Purpose: To evaluate the toxicity and treatment response of using volumetric modulated arc therapy (VMAT) and chemotherapy as neoadjvuant concurrent chemoradiotherapy (CCRT) for rectal cancer.
Materials and Methods: Ten patients with stage IIA-IV rectal adenocarcinoma who underwent neoadjuvant CCRT using prone-position VMAT from April 2010 to December 2010 were enrolled in this study. All patients were treated on a belly board with a full bladder. All VMAT plans were designed with the Pinnacle3 9.0 planning system with 45 Gy in 25 fractions. Setup errors were corrected using cone-beam computed tomography weekly or more frequently. Treatment toxicities were graded using the Common Terminology Criteria for Adverse Events v4.0. The chemotherapy regimens were 5-fluorouracil-based, combined with oxaliplatin or mitomycin. Five patients received bevacizumab as a part of the chemotherapy regimen.
Results: All patients completed neoadjuvant CCRT and received post-CCRT surgical resection. Two had pathological complete response (pCR), and both of these received bevacizumab. Nine of 10 patients had T or N downstaging. Only one patient had pathological nodal involvement. The most common toxicities were grade 1 or 2 anal skin reaction and diarrhea. No patient experienced more than grade 3 toxicity. There was no difference in toxicity between patients with or without bevacizumab. The average displacement in longitudinal, lateral, and vertical directions in the whole group was 0.24 cm, 0.21 cm, and 0.37 cm, respectively. The standard deviation of displacement at longitudinal, lateral, and vertical directions ranged from 0.09-0.34 cm, 0.06-0.20 cm, and 0.11-0.52 cm, respectively.
Conclusions: Using VMAT and prone position on a belly board in neoadjuvant CCRT with or without bevacizumab for rectal cancer is feasible and safe. The treatmentrelated toxicity was acceptable and the treatment response was satisfactory. Proneposition technique requires more attention in setup errors.


    

本卷期目次
Therapeutic Radiology and Oncology
ADVANCED THYMIC CARCINOMA: CLINICAL EXPERIENCE AND PROGNOSTIC FACTORS OF 18 PATIENTS/ Chao-Yueh FanYee-Min JenWen-Yen HuangChang-Ming ChenHsing-Lung ChaoChun-Shu LinYu-Fu SuKuen-Tze LinJang-Chun LinCheng-Hsiang Lo
FEASIBILITY STUDY USING PRE-OPERATIVE PRONE-POSITION VOLUMETRIC MODULATED ARC THERAPY AND CHEMOTHERAPY IN LOCALLY ADVANCED RECTAL CANCER/ Chia-Chun WangChiao-Ling TsaiYu-Hsuan ChenJin-Tung LiangMing-Jium ShiehBen-Ren LinYu-Lin LinJason Chia-Hsien Cheng
DOSIMETRIC COMPARISON OF TREATMENT PLANS BETWEEN INTENSITY-MODULATED RADIOTHERAPY, INTENSITY-MODULATED ARC THERAPY AND HELICAL TOMOTHERAPY FOR TOTAL SCALP IRRADIATION/ Chin-Nan ChuChun-Yen YuWen-Tsen ChouShih-Neng YangJi-An LiangShang-Wen Chen
模擬頭頸部病人強度調控放射治療皮膚劑量之假體研究/ 傅筱如羅素花曾玉華徐椿壽蔡維達
PTW 2d-array於強度調控放射治療及體積調控弧形治療劑量驗證之經驗分享/ 洪照雄劉國基陳弘政黃英強賴家玄陳妙芬陳文政
使用電子影像驗證裝置在弧形強度調控放射治療的驗證/ 李秉倫鄭梅君趙良曉劉晉昇劉雪君李玉麟劉裕明王令瑋顏上惠黃英強陳信雄趙敏
放射腫瘤科門診病患接受跨院區轉介之意見調查/ 翁麗慧蔡介生
GENE SEQUENCING FOR SELECTION OF CHEMOTHERAPY DRUGS COMBINED WITH STEREOTACTIC BODY RADIATION THERAPY FOR STAGE IV COLON CANCER: A CASE REPORT/ Yaoru HuangShang-Wen ChenLai-Lei TingChia-Chun KuoJeng-Fong Chiou
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.