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題名:PROGNOSTIC FACTORS AFTER ADJUVANT RADIOTHERAPY IN CERVICAL CANCERS: A RETROSPECTIVE STUDY     (16點)
子宮頸癌輔助性放射線治療的預後因子--回溯性研究
著者:Po-Chun Chen(陳柏均) ;Wen-Shan Liu(劉文山) ;Chien-Hsun Chen(陳建勳) ;Ching-Hsiung Chang(張慶雄) ;Pei-Ling Tang(唐佩玲) ;Chung-Man Leung(梁頌文) ;Yu-Chang Hu(胡渝昌) ;Kuo-Chen Chang(張國楨)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:子宮頸癌 ; 輔助性放射線治療 ; 預後因子 ; Cervical cancer ; Adjuvant radiotherapy ; Prognostic factors
刊名:Therapeutic Radiology and Oncology
頁碼:89-96
語言:英語
摘要: 中文摘要PDF ; 英文摘要PDF

目的:此回溯性研究針對接受過輔助性放射線治療的子宮頸癌患者,研究影響整體存活率及無病存活率的預後因子。
材料與方法:本研究從2000至2006年於高雄榮民總醫院收錄149名接受輔助性放射線治療的子宮頸癌患者。利用單變項與多變項,分析各種可能影響存活率之預後因子。
結果:病患之中位數年齡為55歲。子宮頸癌患者依據分期,IB有102位,IIA有33位,IIB-IVA有14位。分期為IB的五年整體存活率及無病存活率分別為75.2%及65.4%。分期為IIA的五年整體存活率及無病存活率分別為69.7%及70.5%。分期為IIB-IVA的五年整體存活率及無病存活率分別為66.7%及50%。多變項分析顯示子宮旁侵犯以及腺癌顯著影響整體存活率。
結論:子宮旁侵犯以及腺癌類型的組織型態為最重要的預後因子。另外,在我們的研究中,輔助性化療並不能提升存活率。
Purpose: This retrospective study aimed to investigate the prognostic factors influenced the overall and progression-free survival (PFS) in cervical cancer patients who received radical hysterectomy and lymphadenectomy and adjuvant radiotherapy.
Methods: From 2000 to 2006, there were 149 cervical cancer patients treated with surgery and adjuvant radiotherapy in the Department of Radiation therapy, Kaohsiung Veterans General Hospital, Taiwan. Patient characteristics, treatment characteristics and pathologic factors were analyzed using log rank test. The overall survival (OS) and PFS distribution were calculated by Kaplan-Meier method. Multivariate analysis was performed by the Cox regression model.
Result: The median age of this population was 55 years-old (ranged from 25 to 82). There were 102, 33, and 14 patients belonged to FIGO stage IB, IIA and IIB to IVA, respectively. The 5-year OS and PFS were 75.2% and 65.4% in stage IB cervical cancer, 69.7% and 70.5% in stage IIA cervical cancer, and 66.7% and 50% in stage IIB-IVA cervical cancer. In multivariate analysis, the factors of adenocarcinoma (p<0.05) and parametrial invasion (p<0.01) correlated with worse OS and the factors of parametrial invasion (p<0.01) and age <60 (p<0.05) correlated with worse PFS.
Conclusion: Parametrial invasion and histology of adenocarcinoma accounted the most important prognostic factors among other clinical and pathological factors in patients receiving adjuvant radiotherapy. Adjuvant chemotherapy didn’t achieve better survival in our study.


    

本卷期目次
Therapeutic Radiology and Oncology
THE IMPACT OF PRONE POSITION WITH BELLY-BOARD DEVICE ON THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY OF PROSTATE CANCER: DECREASING THE RECTUM COMPLICATION PROBABILITY/ Yu-Ming LiuLiang-Hsiao ChaoChun-Wei WangSang-Hue YenMei-Ling LeeChuen-Mei HsiehYuh-Lin LeePin-I HuangLing-Wei WangCheng-Ying Shiau
評估頭頸部模型使用的TIMO枕與壓克力枕在放射治療中的再現性與舒適度/ 高菁苓林信吟劉煥彰林倩伃范綱行劉義誠陳柏元
癌症多專科團隊會議運作模式與未來展望許維中/ 廖宏恩鍾娜娜王博民詹淑卿
研究overshoot effect對於執行強度調控放射治療之影響及劑量修正/ 王思文游浚彥周文采朱俊男賴姿云翁益強楊世能梁基安
TOMOTHERAPY FOR CERVICAL CANCER WITH BILATERAL TOTAL HIP REPLACEMENT/ Hsin-Hua LeeShi-Long LianChih-Jen Huang
利用放射線治療默克細胞癌淋巴腺轉移的病患--病例報告/ 葉啓源劉芳慧賴鵬安
PROGNOSTIC FACTORS AFTER ADJUVANT RADIOTHERAPY IN CERVICAL CANCERS: A RETROSPECTIVE STUDY/ Po-Chun ChenWen-Shan LiuChien-Hsun ChenChing-Hsiung ChangPei-Ling TangChung-Man LeungYu-Chang HuKuo-Chen Chang
螺旋刀放射治療儀低分次放射治療第四期非小細胞肺癌肺內病灶--單一中心經驗分享/ 李政彥張恆睿楊凱琳柯卉玲黃素禎溫嘉綺季匡華
 
   
 
   

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