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1
題名:SOLITARY EXTRAMEDULLARY PLASMACYTOMA OF THE HEAD AND NECK: TREATMENT OUTCOME IN 6 PATIENTS AND A REVIEW OF LITERATURE    
六例頭頸部髓外漿細胞瘤的治療結果與文獻回顧
著者:Ping-Hsiu Wu(吳秉修) ;Yu-Chang Hu(胡渝昌) ;Ching-Hsiung Chang(張慶雄) ;Chien-Hsun Chen(陳建勳) ;Wen-Shan Liu(劉文山) ;Kuo-Chen Chang(張國禎) ;Chung-Man Leung(梁頌文)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:髓外漿細胞瘤 ; 頭頸部腫瘤 ; 放射線治療 ; Extramedullary plasmacytoma ; Head and neck ; Radiotherapy
刊名:Therapeutic Radiology and Oncology
頁碼:261-271
語言:英語
摘要:
目的:頭頸部的骨髓外漿細胞瘤是一種很少見的疾病。本篇回顧了在我們醫院罹患此疾病患者的治療以及預後。
方法與材料:六名患者(四名男性與兩名女性)在西元1980年與2010年間於本院被診斷為頭頸部髓外漿細胞瘤。患者們的中位診斷年齡為64歲(範圍為54到79歲)。其中有兩名患者只接受手術治療;兩名只接受放射線治療;另外兩名則接受了手術以及術後的輔助放射線治療。放射線治療的總劑量都在50Gy上下。
結果:所有患者的中位追蹤時間為5年。腫瘤原發部位為鼻腔(2名)、鼻竇(2名)、口咽(1名)以及鼻咽(1名)。兩名只接受手術治療的患者後來都出現局部復發的現象,其中一名在經過第二次手術後就得到了控制。有兩名患者接受手術與放射線治療。另外兩名只接受放射線治療的患者之後都沒有局部復發的現象,但是分別於皮膚以及其他骨骼部位出現了遠端轉移疾病。在追蹤期間沒有患者進展成多發性骨髓瘤。所有接受放射線治療的患者都沒有明顯且嚴重的後遺症。這六名患者中有一名因為此疾病而死亡。
結論:四名罹患頭頸部髓外漿細胞瘤的患者在接受單獨或輔助的放射線治療後在局部都得到了良好的控制,但是其中兩名患者之後出現了遠端轉移的病灶。根據這些個案與文獻回顧的結果,放射線治療對於頭頸部髓外漿細胞瘤可為安全且有效的治療方式。
Purpose: Solitary extramedullary plasmacytoma of the head and neck (EMPHN) is a rare disease. The objective of this study was to review the treatment results of EMPHN patients in a single institution in Taiwan.
Methods and Materials: The cases of 6 patients (4 males and 2 females) diagnosed at our hospital with EMPHN between 1980 and 2010 were reviewed. The median age of the patients was 64 years (range, 54-79 years). Two patients underwent surgery alone, 2 patients underwent radiotherapy alone, and 2 patients underwent surgery and adjuvant radiotherapy. The dose of radiotherapy was 50-50.4 grays (Gy) in 25-28 fractions.
Results: The median follow-up duration was 5 years. The primary tumor sites were the nasal cavity (2), paranasal sinuses (2), oropharynx (1), and nasopharynx (1). Local recurrence was observed in 2 patients who underwent surgery alone and local control was achieved in 1 after salvage surgery (no evidence of disease after salvage surgery in the follow up 3 years period). Local control was achieved in 2 patients treated with surgery and adjuvant radiotherapy. Distant metastasis to the skin and bone without evidence of local recurrence was observed in 2 patients treated with radiotherapy alone. None of the patients progressed to multiple myeloma during follow-up evaluations and no severe radiotherapy-related morbidity was observed. One patient who treated with surgery alone died from recurrent EMPHN within the follow-up duration.
Conclusions: Local control of the tumor in the primary site was achieved in 4 patients with EMPHN who underwent radiotherapy alone or adjuvant, although 2 of these patients presented with distant metastasis. According to the review of literature and our results, radiotherapy might be safe and effective for local control of EMPHN.


    

本卷期目次
Therapeutic Radiology and Oncology
DEFINITIVE CONCURRENT CHEMORADIOTHERAPY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA: HIGH DOSE VERSUS STANDARD DOSE RADIATION THERAPY/ Chen-Xiong HsuYu-Wen HuPin-I HuangSheng-Yu ChenYi-Wei ChenLing-Wei WangSang-Hue YenYu-Ming Liu
LONG-TERM OUTCOME OF RADIOTHERAPY FOR MUCOEPIDERMOID CARCINOMA OF THE HEAD AND NECK REGION/ Po-Ju LinJin-Ching Lin
SOLITARY EXTRAMEDULLARY PLASMACYTOMA OF THE HEAD AND NECK: TREATMENT OUTCOME IN 6 PATIENTS AND A REVIEW OF LITERATURE/ Ping-Hsiu WuYu-Chang HuChing-Hsiung ChangChien-Hsun ChenWen-Shan LiuKuo-Chen ChangChung-Man Leung
鼻咽癌二次定位計劃中腫瘤及腮腺體積變化的臨床動態研究/ 黃昭明黃文濤鄭鴻鈞徐椿壽
加馬刀與電腦刀應用於動靜脈畸形治療之臨床評估比較與劑量差異分析/ 郭駿騵蕭安成蘇鈺凱張智傑余孝緯黃聖芳陳藜臻林家瑋蔡若婷
A PLANNING STUDY FOR FEASIBILITY OF APPLYING VOLUMETRIC-MODULATED ARC THERAPY FOR LOCALLY ADVANCED HEAD AND NECK CANCER/ Chou-Hsien LeeWen-Shan LiuHsien-Chun TsengHsi-Chang ChangYing-Hsiang ChouShao-Ti LiHsiu-Ting Hsu
MERKEL CELL CARCINOMA OF LOWER EXTREMITY: A CASE REPORT AND REVIEW OF THE LITERATURES/ Chen-Ta WuWen-Lin HsuYung-Hsiang HsuTsai-Ying HuangDai-Wei Liu
UNUSUAL OLIGOMETASTASES OF DISTANT NODES AS THE INITIAL RELAPSE SITE OF UTERINE SARCOMA: A CASE REPORT/ Pei-Wei ShuengChristopher HoMing-Chow WeiChien-Chen TsaiChen-Hsi Hsieh
 
   
 
   

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