原名「台灣學術線上」
包含TAO期刊庫 + TAO書籍庫 + 論文 + 史料文獻
首頁 | 關於TAO | 瀏覽 | 進階查詢 | 參考工具 | 會員服務 | 已購專書 | RSS服務 | 電子報 | FAQ  
查詢範圍:
   
查詢模式:
熱門查詢詞:
dvd與神對話工具機 調機皮膚老化
   
   
   
     
   
 
項次 書目
1
題名:加馬刀與電腦刀應用於動靜脈畸形治療之臨床評估比較與劑量差異分析     (24點)
Clinical evaluation and dosimetric comparison of Gamma Knife and CyberKnife treatment plans for arteriovenous malformations
著者:郭駿騵(Chun-Yuan Kuo) ;蕭安成(An-Cheng Shiau) ;蘇鈺凱(Yu-Kai Su) ;張智傑(Chih-Chieh Chang) ;余孝緯(Hsiao-Wei Yu) ;黃聖芳(Sheng-Fang Huang) ;陳藜臻(Li-Jhen Chen) ;林家瑋(Jia-Wei Lin) ;蔡若婷(Jo-Ting Tsai)
出版地區:台灣
出版城市:台北市
學科:醫學綜合
關鍵字:加馬刀 ; 電腦刀 ; 動靜脈畸形 ; Gamma Knife ; CyberKnife ; Arteriovenous malformations
刊名:放射治療與腫瘤學
頁碼:281-292
語言:繁體中文
摘要: 中文摘要PDF ; 英文摘要PDF

目的:分析比較加馬刀(Gamma Knife®)與電腦刀(Cyber Knife®)兩種放射手術設備,應用於動靜脈畸形(Arteriovenous malformations, AVMs)病例之治療時,其兩者因臨床治療運用技術及機械結構迥異,所造成劑量分佈的變化情形;並探討與評估此劑量分佈的特性於臨床治療應用上之差異及其影響。
材料與方法:選擇10位接受過電腦刀治療的AVM患者,單次處方劑量為20-25Gy,取得其電腦治療計畫。此外,將電腦刀治療計畫的CT影像、靶體積與周邊危急器官輪廓檔案,自電腦刀電腦治療計畫系統輸出後,轉輸入加馬刀電腦治療計畫系統,依相同處方劑量,完成加馬刀的電腦治療計畫。比較10位病患的電腦刀與加馬刀治療計畫的劑量順形度、劑量梯度與劑量異質性指標,10、12Gy所涵蓋範圍之體積,腦幹的最大劑量以及照射的時間。在統計分析的部分,劑量順形度與劑量梯度指標,10、12Gy所涵蓋範圍之體積的比較是以Paired Samplest-test來執行,求取p值後評估兩種治療計畫在所比較之項目是否存在著顯著的差異。
結果:加馬刀與電腦刀的劑量順形度指標統計值分別為0.626±0.106及0.795±0.087,p=0.004。加馬刀與電腦刀的劑量梯度指標統計值分別為3.082±0.369及6.071±1.698,p=0.001。加馬刀與電腦刀的劑量異質性指標分別為0.723±0.055及0.275±0.045。10與12Gy劑量體積的統計分析p值分別為0.025與0.022。3位AVM位置鄰近腦幹的病例,在腦幹組織1c.c.體積劑量與腦幹最大劑量比較,加馬刀皆小於電腦刀。在效能的比較上,電腦刀所需的照射時間則較短。
結論:電腦刀因為使用逆向式治療計畫且形成類似強度調控的功能,因此較易求得較佳的劑量順形度。在周邊正常組織劑量豁免的部分,則是加馬刀有較佳的表現,可預期加馬刀可使正常腦組織與鄰近之危急器官得到較佳的保護。
To analyze and compare the dose distribution characteristic of two radiosurgery treatment devices of Gamma Knife®(GK) and CyberKnife® (CK), in treating arteriovenous malformations (AVMs) and the influence on their clinical application.
Ten AVM patients treated with CK of prescribed dose of 20-25 Gy in single fraction were evaluated. Each treatment plan CT images including the contours of the target and the surrounding critical organs were exported and loaded into the GK treatment planning system. GK treatment plan using the same prescribed radiation dose were generated. Dosimetric comparison of the two treatment devices including the conformity, gradient and heterogeneity index, volume of brain tissue covered by 10 Gy and 12 Gy, maximum dose of brain stem and the beam on time. Paired Samples t-test was used to statistical analyze and compare the conformal and gradient index, the dose coverage volume of 10 Gy and 12 Gy in both plans for significance (p value).
The conformal index was 0.626 ± 0.106 and 0.795 ± 0.087 in GK and CK, respectively (p=0.004). The gradient index was 3.082 ± 0.369 and 6.071 ± 1.698 in GK and CK, respectively (p=0.001). The heterogeneity index was 0.723±0.055 and 0.275±0.045 in GK and CK, respectively. The difference of coverage volume of 10 Gy and 12 Gy were significant (p=0.025 and 0.022, respectively). For the 3 cases with AVM location adjacent to the brainstem, the dose of 1 c.c. and maximum dose of brain stem in GK plan were less than CK. CK had better treatment efficiency due to shorter beam on time.
CyberKnife using inverse treatment planning similar to intensity modulated function had better dose conformity. Gamma Knife should have better normal brain tissue and critical organs protection due to sharp dose fall-off gradient.


    

本卷期目次
放射治療與腫瘤學
DEFINITIVE CONCURRENT CHEMORADIOTHERAPY IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA: HIGH DOSE VERSUS STANDARD DOSE RADIATION THERAPY/ Chen-Xiong HsuYu-Wen HuPin-I HuangSheng-Yu ChenYi-Wei ChenLing-Wei WangSang-Hue YenYu-Ming Liu
LONG-TERM OUTCOME OF RADIOTHERAPY FOR MUCOEPIDERMOID CARCINOMA OF THE HEAD AND NECK REGION/ Po-Ju LinJin-Ching Lin
SOLITARY EXTRAMEDULLARY PLASMACYTOMA OF THE HEAD AND NECK: TREATMENT OUTCOME IN 6 PATIENTS AND A REVIEW OF LITERATURE/ Ping-Hsiu WuYu-Chang HuChing-Hsiung ChangChien-Hsun ChenWen-Shan LiuKuo-Chen ChangChung-Man Leung
鼻咽癌二次定位計劃中腫瘤及腮腺體積變化的臨床動態研究/ 黃昭明黃文濤鄭鴻鈞徐椿壽
加馬刀與電腦刀應用於動靜脈畸形治療之臨床評估比較與劑量差異分析/ 郭駿騵蕭安成蘇鈺凱張智傑余孝緯黃聖芳陳藜臻林家瑋蔡若婷
A PLANNING STUDY FOR FEASIBILITY OF APPLYING VOLUMETRIC-MODULATED ARC THERAPY FOR LOCALLY ADVANCED HEAD AND NECK CANCER/ Chou-Hsien LeeWen-Shan LiuHsien-Chun TsengHsi-Chang ChangYing-Hsiang ChouShao-Ti LiHsiu-Ting Hsu
MERKEL CELL CARCINOMA OF LOWER EXTREMITY: A CASE REPORT AND REVIEW OF THE LITERATURES/ Chen-Ta WuWen-Lin HsuYung-Hsiang HsuTsai-Ying HuangDai-Wei Liu
UNUSUAL OLIGOMETASTASES OF DISTANT NODES AS THE INITIAL RELAPSE SITE OF UTERINE SARCOMA: A CASE REPORT/ Pei-Wei ShuengChristopher HoMing-Chow WeiChien-Chen TsaiChen-Hsi Hsieh
 
   
 
   

與TAO合作 | 隱私與版權聲明 | 聯絡方式 | 下載Adobe Reader
地址:台北市中正區(100)北平東路30-12號3樓
電話:(02)2393-6968 傳真:(02)2393-6877
Email: service@wordpedia.com
Wordpedia Family: 學校、企業版入口 | 遠流影音館
Copyright©2011 Wordpedia Co., Ltd. All Rights Reserved.